# cogena [](http://bioconductor.org/packages/cogena) [](http://github.com/zhilnogjia/cogena) [](https://www.bioconductor.org/packages/devel/bioc/html/cogena.html#since) [](http://www.bioconductor.org/packages/devel/bioc/html/cogena.html) [](http://bioconductor.org/packages/stats/bioc/cogena) ## Introduction To discovery smaller scale, but highly correlated cellular events that may be of great biological relevance, co-expressed gene set enrichment analysis, cogena, aims to cluster gene expression profiles (coExp) for gene co-expression analysis and then implement enrichment analysis for each clusters (clEnrich) based on hyper-geometric test. The results can be visulised by heatmapCluster and heatmapPEI. Based on different gene sets used, cogena can be used as a tool for pathway analysis, GO enrichment analysis, drug repositioning and so on. See [vignette](http://bioconductor.org/packages/devel/bioc/vignettes/cogena/inst/doc/cogena-vignette_html.html) for the detailed workflow. The version of cogena at github is also availiable at [Bioconductor](http://www.bioconductor.org/packages/devel/bioc/html/cogena.html) (development version) ## The workflow of cogena  ## Installation devtools::install_github("zhilongjia/cogena") ## Help [cogena in Biostars](https://www.biostars.org/p/137330/) ## Citation [Jia, Zhilong, et al. "Cogena, a novel tool for co-expressed gene-set enrichment analysis, applied to drug repositioning and drug mode of action discovery." BMC Genomics 17.1 (2016): 1.](http://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2737-8) ## Acknowledgement cogena was originally based on the [clValid](http://cran.r-project.org/web/packages/clValid/index.html) package.