\name{PredTarget} \alias{PredTarget} \title{ Prediction of the most similar known targeted gene. } \description{ Predicts the gene that has the most similarity to a drug’s response scores. This is done based on selecting a gene that has the most correlation across the known targeted genes by their drug. } \usage{ PredTarget(Sim.GES.DRS,D.M) } \arguments{ \item{Sim.GES.DRS}{similarity between Drug’s response scores and Gene effect scores from Knock-out method such as CRISPR.} \item{D.M}{Drug Metadata} } \value{ a dataframe of drug(s) information with the most known predicted gene(s) with the max corelation value(s), P value(s), and FDR value(s). } \author{ sanjusinha7, Trinh Nguyen } \examples{ library(BiocParallel) data(OntargetM) set.seed (12345) All.Drugs <- OntargetM$DrugMetadata[,"broad_id_trimmed"] S.Drugs <- sample(All.Drugs, 5) KO.GES <- OntargetM$avana_CRISPR sec.prism <- OntargetM$secondary_prism sim.out <- bplapply(S.Drugs,function(x) computeCor(x,sec.prism,KO.GES)) names(sim.out) <- S.Drugs Meta.data <- OntargetM$DrugMetadata DrugTargetSim <- PredTarget(sim.out,Meta.data) }