# receptLoss <!-- badges: start --> [](https://travis-ci.org/dpique/receptLoss) <!-- badges: end -->  This package contains functions to detect nuclear hormone **recept**or (NHR) expression **loss** (**receptLoss**) in subsets of tumors relative to normal tissue. * `receptLoss`: the main function in this package. * Input: 2 matrices of expression data, one from tumor and one from adj normal tissue. * Output: Table of summary statistics, with each row as a gene and each column a separate statistic. The table's rows are sorted by delta mu value, which reflects the degree of separation between tumor subgroups. * `plotReceptLoss`: A function to visualize the output from receptLoss for a particular gene. It also includes a dataset consisting of all known NHRs: * `nhrs` (Source: http://www.guidetopharmacology.org/DATA/targets_and_families.csv) `receptLoss` is complementary to [`oncomix`](https://github.com/dpique/oncomix). Whereas `oncomix` detects the **gain** of gene expression in subsets of tumors relative to normal tissue, `receptLoss` detects the **loss** of gene expression in subsets of tumors relative to normal tissue. ## Installation ```R ## Install the development version of receptLoss from github devtools::install_github("dpique/receptLoss", build_opts=c("--no-resave-data", "--no-manual"), build_vignettes=TRUE) ## open the vignette vignette("receptLoss") ```