# powerTCR: modeling the clone size distribution of the TCR repertoire This is an R package for fitting the discrete gamma-GPD spliced threshold model to a distribution of clone sizes. The package contains tools needed to perform all of the analyses found in our paper, *powerTCR: a model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire.* ## Installation Install and load this package from BioConductor by typing in R: ```{r} if (!requireNamespace("BiocManager", quietly=TRUE)) install.packages("BiocManager") BiocManager::install("powerTCR") ``` or take it directly from from GitHub with: ```{r} library(devtools) install_github("hillarykoch/powerTCR") library(powerTCR) ``` ## Getting going See the [package vignette](/vignettes/powerTCR.Rmd) for a detailed walkthrough of package features. ## Citation You may read our methods paper at [PLoS Computational Biology](https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1006571). If you found the powerTCR package useful, please cite our paper: Koch H, Starenki D, Cooper SJ, Myers RM, Li Q (2018) powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire. PLOS Computational Biology 14(11): e1006571. https://doi.org/10.1371/journal.pcbi.1006571 Citation for the powerTCR package is: Koch H (2018). powerTCR: Model-Based Comparative Analysis of the TCR Repertoire. R package version 1.1.4.