setMethod("initialize", signature(.Object="GenomeAnnotatedDataFrame"),
	  function(.Object,
		   position=integer(),
		   isSnp=vector("logical", length(position)),
		   chromosome=vector("integer", length(position)),
		   row.names=NULL,
		   data,
		   varMetadata,
		   ...){
		  if(missing(data))
			  data <- data.frame(isSnp=isSnp, position=position, chromosome=chromosome, ..., row.names=row.names)
		  if(missing(varMetadata)){
			  nms <- names(list(...))
			  varMetadata <- data.frame(labelDescription=c("SNP indicator", "physical position", "chromosome", nms))
		  }
		  .Object <- callNextMethod(.Object, data=data, varMetadata=varMetadata)
	  })

setMethod("updateObject", signature(object="GenomeAnnotatedDataFrame"),
	  function(object, ..., verbose=FALSE){
		  ##as(object, "GenomeAnnotatedDataFrame")
		  ADF2GDF(object)
	 })

setMethod("coerce", signature(from="AnnotatedDataFrame", to="GenomeAnnotatedDataFrame"),
	  function(from, to){
		  new("GenomeAnnotatedDataFrame",
		      isSnp=as.logical(from$isSnp),
		      position=as.integer(from$position),
		      chromosome=as.integer(from$chromosome),
		      row.names=featureNames(from))
	  })

ADF2GDF <- function(object){
	new("GenomeAnnotatedDataFrame",
	    isSnp=as.logical(object$isSnp),
	    position=as.integer(object$position),
	    chromosome=as.integer(object$chromosome),
	    row.names=featureNames(object))
}


isValidGenomeAnnotatedDataFrame <- function(object){
		    if(!all(c("isSnp", "position", "chromosome") %in% varLabels(object)))
			    return("'isSnp', 'position', and 'chromosome' are required varLabels of the AnnotatedDataFrame for features")
		    if(!is(chromosome(object), "integer") || !is(position(object), "integer"))
			    return("chromosome and position must be integers. See function 'chromosome2integer'")
		    if(!is.logical(isSnp(object))){
			    return("isSnp must be logical")
		    }
		    TRUE
}

setValidity("GenomeAnnotatedDataFrame",
	    function(object){
		    msg <- isValidGenomeAnnotatedDataFrame(object)
		    if(is.character(msg)) return(msg)
	    })

setMethod("GenomeAnnotatedDataFrameFrom",
	  signature(object="ff_or_matrix"),
	  function(object, annotationPkg, genome="hg19", ...){
		  GenomeAnnotatedDataFrameFromMatrix(object=object, annotationPkg=annotationPkg, genome=genome, ...)
})

setMethod("GenomeAnnotatedDataFrameFrom", signature(object="array"),
	  function(object, annotationPkg, genome="hg19", ...){
		  GenomeAnnotatedDataFrameFromArray(object, annotationPkg, genome=genome,  ...)
	  })

setMethod("GenomeAnnotatedDataFrameFrom",
	  signature(object="NULL"),
	  function(object, annotationPkg, genome="hg19", ...){
		  GenomeAnnotatedDataFrameFromNULL(object)
})

setMethod("GenomeAnnotatedDataFrameFrom",
	  signature(object="list"),
	  function(object, annotationPkg, genome="hg19", ...){
		  GenomeAnnotatedDataFrameFromList(object, annotationPkg, genome=genome, ...)
	  })

setMethod("GenomeAnnotatedDataFrameFrom",
	  signature(object="AssayData"),
	  function(object, annotationPkg, genome="hg19", ...){
		  GenomeAnnotatedDataFrameFromAssayData(object=object, annotationPkg=annotationPkg, genome=genome, ...)
})

GenomeAnnotatedDataFrameFromMatrix <- function(object,
					       annotationPkg,
					       genome,
					       ...){
  dims <- dim(object)
  if (is.null(dims) || all(dims==0)){
    object <- GenomeAnnotatedDataFrameFrom(NULL, ...)
  } else {
    nms <- rownames(object)
    if(!is.null(nms)){
      if(any(is.na(nms))) warning("NA's in rownames")
    }
    if(length(annotationPkg)==0 | is.null(nms)){
      n <- dims[1]
      data <- data.frame(position=integer(n),
                         chromosome=integer(n),
                         isSnp=logical(n),
                         row.names=nms)
      object <- new("GenomeAnnotatedDataFrame", data=data)
    } else {
      stopifnot(isSupportedAnnotation(annotationPkg))
      is.pd <- isPdAnnotationPkg(annotationPkg)
      if(is.pd){
        object <- addFeatureAnnotation.pd2(annotationPkg, featureNames=rownames(object), genome=genome,...)
      } else {
        object <- addFeatureAnnotation.crlmm2(annotationPkg, featureNames=rownames(object), genome=genome, ...)
      }
    }
  }
  return(object)
}



GenomeAnnotatedDataFrameFromArray <- function(object, annotationPkg, ...){
  ## coerce to matrix
  dims <- dim(object)
  is.array <- length(dims) == 3
  if(is.array){
    res <- GenomeAnnotatedDataFrameFromMatrix(object[, , 1], annotationPkg, ...)
  } else {
    ##dim(object) <- dim(object)[c(1,2)]
    res <- GenomeAnnotatedDataFrameFromMatrix(object, annotationPkg, ...)
  }
  res
}

GenomeAnnotatedDataFrameFromList <- function(object, annotationPkg, genome){
	##if(length(object)==0) return(GenomeAnnotatedDataFrameFromNULL(NULL))
	if(length(object)==0) return(object)
	nms <- ls(object)
	elt <- object[[nms[1]]]
	fdlist <- vector("list", length(elt))
	for(i in seq_along(elt)){
		fdlist[[i]] <- GenomeAnnotatedDataFrameFrom(elt[[i]], annotationPkg, genome)
	}
	return(fdlist)
}

GenomeAnnotatedDataFrameFromNULL <- function(object, byrow=TRUE, ...) {
	new("GenomeAnnotatedDataFrame")
}

GenomeAnnotatedDataFrameFromAssayData <- function(object, annotationPkg, ...) {
    eltNames <-
        if (is(object, "environment")) ls(object)
        else names(object)
    if (length(eltNames)==0)
	    GenomeAnnotatedDataFrameFrom(NULL)
    else
        GenomeAnnotatedDataFrameFrom(object[[eltNames[1]]], annotationPkg, ...)
}



setMethod("isSnp", signature(object="GenomeAnnotatedDataFrame"),
	  function(object) object$isSnp)
setMethod("position", signature(object="GenomeAnnotatedDataFrame"),
	  function(object, ...) object$position)
setMethod("chromosome", signature(object="GenomeAnnotatedDataFrame"),
	  function(object, ...) object$chromosome)
setReplaceMethod("chromosome", signature(object="GenomeAnnotatedDataFrame",
					 value="integer"),
		 function(object, value){
			 fData(object)$chromosome <-  value
			 object
		 })
setReplaceMethod("isSnp", signature(object="GenomeAnnotatedDataFrame",
				    value="logical"),
		 function(object, value){
			 Biobase::fData(object)$isSnp <-  value
			 object
		 })
setReplaceMethod("position", signature(object="GenomeAnnotatedDataFrame",
				       value="integer"),
		 function(object, value){
			 Biobase::fData(object)$position <-  value
			 object
		 })

isPdAnnotationPkg <- function(object) length(grep("pd.", object)) >= 1

addFeatureAnnotation.pd2 <- function(annotation, featureNames, genome){
	##message("Adding required feature annotation (chromosome, position, isSnp) to featureData slot")
	fs <- featureNames
	tmp <- paste("('", paste(fs, collapse="', '"), "')", sep="")
	fD <- matrix(integer(), length(fs), 3)
	rownames(fD) <- fs
	colnames(fD) <- c("chromosome", "position", "isSnp")
	sql <- paste("SELECT man_fsetid, chrom, physical_pos FROM featureSet WHERE man_fsetid IN ", tmp)
	##Check if two objects have been combined
	pkgs <- strsplit(annotation, ",")[[1]]
	snps <- snp.index <- nps <- np.index <- vector("list", length(pkgs))
	for(i in seq(along=pkgs)){
		annotation <- pkgs[i]
		requireAnnotation(annotation)
		annoObject <- get(annotation)
		gb <- tolower(genomeBuild(annoObject))
		if(gb != genome){
			stop(paste("Genome build in package ",
				   annotation, " is ", gb, ", but build ",
				   genome, " is requested.", sep=""))
		}
                snps[[i]] <- dbGetQuery(annoObject@getdb(), sql)
		snp.index[[i]] <- match(snps[[i]]$man_fsetid, rownames(fD))
		if("featureSetCNV" %in% dbListTables(annoObject@getdb())){
			sql <- paste("SELECT man_fsetid, chrom, chrom_start FROM featureSetCNV WHERE man_fsetid IN ", tmp)
			nps[[i]] <- dbGetQuery(annoObject@getdb(), sql)
			np.index[[i]] <- match(nps[[i]]$man_fsetid, rownames(fD))
		}
	}
	if(length(snps) > 1){
		snps <- do.call(rbind, snps)
		snp.index <- unlist(snp.index)
		if("featureSetCNV" %in% dbListTables(annoObject@getdb())){
			nps <- do.call(rbind, nps)
			np.index <- unlist(np.index)
		}
	} else {
		snps <- snps[[1]]
		snp.index <- snp.index[[1]]
		if("featureSetCNV" %in% dbListTables(annoObject@getdb())){
			nps <- nps[[1]]
			np.index <- np.index[[1]]
		}
	}
	fD[snp.index, "isSnp"] <- as.integer(1)
	fD[snp.index, "chromosome"] <- chromosome2integer(snps$chrom)
	fD[snp.index, "position"] <- as.integer(snps$physical_pos)
	if("featureSetCNV" %in% dbListTables(annoObject@getdb())){
		fD[np.index, "isSnp"] <- as.integer(0)
		fD[np.index, "chromosome"] <- chromosome2integer(nps$chrom)
		fD[np.index, "position"] <- as.integer(nps$chrom_start)
	}
	featureData <- new("GenomeAnnotatedDataFrame",
			   isSnp=as.logical(fD[, "isSnp"]),
			   chromosome=as.integer(fD[, "chromosome"]),
			   position=as.integer(fD[, "position"]),
			   row.names=featureNames)
	return(featureData)
}




addFeatureAnnotation.crlmm2 <- function(object, featureNames, genome="hg19", ...){
  nm <- grep("Crlmm", object, ignore.case=TRUE)
  if(length(nm) == 0){
    pkgname <- paste(object, "Crlmm", sep="")
  } else pkgname <- object
  path <- system.file("extdata", package=pkgname)
  if(path=="") stop("Are you sure ", pkgname, " is installed?")
  ## Most of our annotation packages have only hg19 build
  snpBuilds <- list.files(path, pattern="snpProbes_")
  build <- gsub(".rda", "", gsub("snpProbes_", "", snpBuilds))
  if(length(build) > 1){
    if(genome %in% build){
      build <- genome
    } else 	{ ## genome not in build
      message(paste("Builds", paste(build, collapse=","), "are available. Use genome=[build] to specify which build to use for annotation."))
      build <- build[1]
    }
  }
  if(length(build)==1){
    if(build != genome){
      message(paste("Build", genome, "requested, but only build", build, "is available."))
    }
    loader(paste("cnProbes_", build, ".rda", sep=""), pkgname=pkgname, envir=.oligoClassesPkgEnv)
    loader(paste("snpProbes_", build, ".rda", sep=""), pkgname=pkgname, envir=.oligoClassesPkgEnv)
  } else { ## length of build is zero
    ## file not found (older version of annotation packages).  allow processing to continue
    loader("cnProbes.rda", pkgname=pkgname, envir=.oligoClassesPkgEnv)
    loader("snpProbes.rda", pkgname=pkgname, envir=.oligoClassesPkgEnv)
  }
  cnProbes <- get("cnProbes", envir=.oligoClassesPkgEnv)
  snpProbes <- get("snpProbes", envir=.oligoClassesPkgEnv)
  snpProbes <- snpProbes[rownames(snpProbes) %in% featureNames, , drop=FALSE]
  cnProbes <- cnProbes[rownames(cnProbes) %in% featureNames, , drop=FALSE]
  ##Feature Data
  isSnp <- 1L-as.integer(featureNames %in% rownames(cnProbes))
  names(isSnp) <- featureNames
  if(any(isSnp)){
    snps <- featureNames[isSnp == 1]
    index <- match(snps, rownames(snpProbes))
    position.snp <- snpProbes[index, "position"]
    names(position.snp) <- snps
    J <- grep("chr", colnames(snpProbes))
    chr.snp <- snpProbes[index, J]
  } else{
    warning("None of the featureNames in the object match SNP probes for the indicated annotation package.  Either the annotation package is misspecified, or the featureNames of the object are incorrect")
    message("The annotation for the object is ", object)
    chr.snp <- position.snp <- integer()
  }
  if(any(!isSnp)){
    nps <- featureNames[isSnp == 0]
    index <- match(nps, rownames(cnProbes))
    position.np <- cnProbes[index, "position"]
    names(position.np) <- nps
    chr.np <- cnProbes[index, J]
  } else {
    chr.np <- position.np <- integer()
  }
  position <- c(position.snp, position.np)
  chrom <- c(chr.snp, chr.np)
  ##We may not have annotation for all of the snps
  if(!all(featureNames %in% names(position))){
    warning("physical position not available for all featureNames")
  }
  ix <- match(featureNames, names(position))
  position <- position[ix]
  chrom <- chrom[ix]
  ##require(SNPchip)
  chrom <- chromosome2integer(chrom)
  stopifnot(identical(names(position), featureNames))
  if(sum(duplicated(names(position))) > 0){
    warning("Removing rows with NA identifiers...")
    ##RS: fix this
    I <- which(!is.na(names(position)))
  }  else I <- seq(along=names(position))
  new("GenomeAnnotatedDataFrame",
      isSnp=as.logical(isSnp[I]),
      position=as.integer(position[I]),
      chromosome=as.integer(chrom[I]),
      row.names=featureNames)
}

cleancdfname <- function(x) strsplit(x, "Crlmm")[[1]][[1]]

isSupportedAnnotation <- function(x){
	validAnn <- annotationPackages()
	validAnn <- validAnn[-grep(",", validAnn)]
	stripCrlmm <- sapply(validAnn, cleancdfname)
	validAnn <- unique(c(validAnn, stripCrlmm))
	x <- strsplit(x, ",")[[1]]
	for(i in seq_along(x)) match.arg(x[i], validAnn)
	return(TRUE)
}

annotationPackages <- function(){
	c("pd.mapping50k.hind240", "pd.mapping50k.xba240",
	  "pd.mapping50k.hind240,pd.mapping50k.xba240",
	  "pd.mapping250k.nsp",
	  "pd.mapping250k.sty",
	  "pd.mapping250k.nsp,pd.mapping250k.sty",
	  "pd.genomewidesnp.5",
	  "pd.genomewidesnp.6",
	  "genomewidesnp6Crlmm",
	  "genomewidesnp5Crlmm",
	  "human370v1cCrlmm",
	  "human370quadv3cCrlmm",
	  "human550v3bCrlmm",
	  "human650v3aCrlmm",
	  "human610quadv1bCrlmm",
	  "human660quadv1aCrlmm",
	  "human1mduov3bCrlmm",
	  "humanomni1quadv1bCrlmm")
}

affyPlatforms <- function(){
  platforms <- c("pd.mapping50k.xba240",
                 "pd.mapping50k.hind240",
                 "pd.mapping250k.nsp",
                 "pd.mapping250k.sty",
                 "pd.genomewidesnp.5",
                 "pd.genomewidesnp.6")
  combined <- rep(NA, 2)
  combined[1] <- paste(sort(platforms[1:2]), collapse=",")
  combined[2] <- paste(sort(platforms[3:4]), collapse=",")
  platforms <- c(platforms, combined)
  platforms
}


checkAnnotation <- function(x){
	if(length(x) == 0) return(FALSE)
	x <- strsplit(x, ",")[[1]]
	if(length(x) == 1){
		istrue <- isSupportedAnnotation(x)
	} else {
		istrue <- sapply(x, isSupportedAnnotation)
		istrue <- all(istrue)
	}
	return(istrue)
}

setReplaceMethod("position", signature(object="oligoSnpSet", value="integer"),
		 function(object, value){
			 position(featureData(object)) <- value
			 object
		 })

setReplaceMethod("position", signature(object="GenomeAnnotatedDataFrame", value="integer"),
		 function(object, value){
			 object$position <- value
			 object
		 })

setMethod("makeFeatureGRanges", signature(object="GenomeAnnotatedDataFrame"),
	  function(object, genome, ...){
		  chr.names <- c(paste("chr", 1:22, sep=""), "chrX", "chrY")
		  sl <- getSequenceLengths(genome)
		  sl <- sl[chr.names]
		  chrom <- paste("chr", integer2chromosome(chromosome(object)), sep="")
		  if(!all(chrom %in% chr.names)) stop("chromosomes must be chr1, ... chr22, chrX, or chrY")
		  gr <- GRanges(chrom,
				IRanges(position(object), width=1),
				seqlengths=sl)
		  names(gr) <- sampleNames(object)
		  metadata(gr) <- list(genome=genome)
		  return(gr)
	  })

setMethod("getArm", signature(object="GenomeAnnotatedDataFrame"), function(object, genome){
	genome <- match.arg(genome, c("hg18","hg19"))
	.getArm(chromosome(object), position(object), genome)
})