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Microbiome Differential Abundance Simulation ================ [![Bioc build](]( [![Bioc time](]( [![Bioc downloads](]( This package is developed to simulate microbiome data for longitudinal differential abundance analyses. Microbiome data have a variety of features that make typical simulation methods inappropriate. For an in-depth description of the types of problems this simulation package is designed to solve, plus basics of the functionality please refer to the F1000 manuscript [f1000research.20660.2]( ## Installation To install the `microbiomeDASim` package the latest release version is available from Bioconductor ``` r if (!requireNamespace("BiocManager", quietly = TRUE)) install.packages("BiocManager") BiocManager::install("microbiomeDASim") ``` Alternatively to use the latest development version from Bioconductor use the following commands ``` r if (!requireNamespace("BiocManager", quietly = TRUE)) install.packages("BiocManager") BiocManager::install("microbiomeDASim", version="devel") ``` ## Examples An interactive examples for how to simulate data from a multivariate normal distribution and fit a trend line using [metagenomeSeq::fitTimeSeries]( are available in the `inst/scripts` directory. This notebook can be run interactively using Google Collab by clicking the “Open in Colab” marker at the top of the notebook.