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# epihet Introduction epiHet is a R package to calculate the intra-tumoral epigenetic heterogeneity and performing differentially epigenetic heterogeneity analysis from high-throughput bisulfite sequencing. epihet implements a biological network analysis workflow for transforming cancer type-specific differentially epigenetic heterogeneity loci into cancer-related biological function and clinical biomarker. How to use The input bam file may be obtained from bisseq pipeline ( for aligning bisulfite sequencing reads.