## IMPORTANT - move IRanges and oligoClasses back to Suggests? BC moved them to Depends just to get rid of annoying warnings while transitioning. ##################################### ### FOR CRLMM ##################################### - Add RS ids to annotation packages - Allele plots - M v S plots R. Scharpf (after next release) - crlmm should return a SnpSet object with elements A, B, calls, and confs in the assayData when save.it=TRUE. These objects can be very big, so... - crlmm function should have an option to return nothing and write to file a SnpSet object for each chromosome. This would help the copy number part that runs by chromosome B Carvalho - crlmm should return results in CHP files - crlmm2() with save.it=TRUE must save the original preprocessed intensities *********************************************************** * * * FOR CNRMA * * * *********************************************************** o Bias adjustment for X chromosome o Adjust nu for altered copy number (crosshyb) o Should store parameters in something besides the featureData slot - Perhaps add a matrix slot for parameters and a slot for batch. - Need accessors - how to store parameters for chromosome X (should be nu_A_male, nu_A_female, etc.)? o Provide a SNP- and sample-specific estimate of the variance for computing emission probabilities. (Currently, only SNP-specific) (DONE -- version 1.3.10 o Allow a copy-neutral ROH state by not having an equal prior on the ellipses. For instance, normal state: 1/4 AA, 1/2 AB, 1/4 BB copy-neutral ROH: (1-epsilon)/2 AA, epsilon AB, (1-epsilon)/2 BB o Define a class that contains settings for genotyping/copynumber estimation