getSigma2 <- function(object){ phi.a <- phiA(object) phi.b <- phiB(object) cbind(phi.a, phi.b) } getCor <- function(object, gt){ if(gt =="NULL") return(rep(0, nrow(object))) assayDataElement(batchStatistics(object), paste("corr", gt, sep="")) } getTau2 <- function(object, gt){ bs <- batchStatistics(object) nma <- paste("tau2A", gt, sep=".") nmb <- paste("tau2B", gt, sep=".") tau2.a <- assayDataElement(bs, nma) tau2.b <- assayDataElement(bs, nmb) cbind(tau2.a, tau2.b) } getVar <- function(object, nm){ bs <- batchStatistics(object) assayDataElement(bs, nm) } setMethod("nuA", signature=signature(object="CNSet"), function(object) nu(object, "A")) setMethod("nuB", signature=signature(object="CNSet"), function(object) nu(object, "B")) setMethod("phiA", signature=signature(object="CNSet"), function(object) phi(object, "A")) setMethod("phiB", signature=signature(object="CNSet"), function(object) phi(object, "B")) setMethod("phiPrimeA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "phiPrimeA") }) setMethod("phiPrimeB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "phiPrimeB") }) setMethod("tau2A", signature=signature(object="CNSet"), function(object) tau2(object, "A")) setMethod("tau2B", signature=signature(object="CNSet"), function(object) tau2(object, "B")) setMethod("Ns", signature=signature(object="CNSet"), function(object, ...){ Ns(batchStatistics(object), ...) }) setMethod("corr", signature=signature(object="CNSet"), function(object, ...){ corr(batchStatistics(object), ...) }) setMethod("medians", signature=signature(object="CNSet"), function(object, ...){ medians(batchStatistics(object), ...) }) setMethod("mads", signature=signature(object="CNSet"), function(object, ...){ mads(batchStatistics(object), ...) }) setMethod("tau2", signature=signature(object="CNSet"), function(object, ...){ tau2(batchStatistics(object), ...) }) ##--------------------------------------------------------------------------- ## Number of samples with Genotype AA, AB, or BB by batch setMethod("N.AA", signature=signature(object="CNSet"), function(object){ assayDataElement(batchStatistics(object), "N.AA") }) setMethod("N.AB", signature=signature(object="CNSet"), function(object){ assayDataElement(batchStatistics(object), "N.AB") }) setMethod("N.BB", signature=signature(object="CNSet"), function(object){ assayDataElement(batchStatistics(object), "N.BB") }) setReplaceMethod("N.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "N.AA", value) }) setReplaceMethod("N.AB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "N.AB", value) }) setReplaceMethod("N.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "N.BB", value) }) ##--------------------------------------------------------------------------- ## median intensity by genotype cluster for each allele ##should we update the entire matrix rather than one column... setMethod("medianA.AA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "medianA.AA") }) setMethod("medianA.AB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "medianA.AB") }) setMethod("medianA.BB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "medianA.BB") }) setMethod("medianB.AA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "medianB.AA") }) setMethod("medianB.AB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "medianB.AB") }) setMethod("medianB.BB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "medianB.BB") }) setReplaceMethod("medianA.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "medianA.AA", value) }) setReplaceMethod("medianA.AB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "medianA.AB", value) }) setReplaceMethod("medianA.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "medianA.BB", value) }) setReplaceMethod("medianB.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "medianB.AA", value) }) setReplaceMethod("medianB.AB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "medianB.AB", value) }) setReplaceMethod("medianB.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "medianB.BB", value) }) ##--------------------------------------------------------------------------- ## mad intensity by genotype cluster for each allele setMethod("madA.AA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "madA.AA") }) setMethod("madA.AB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "madA.AB") }) setMethod("madA.BB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "madA.BB") }) setMethod("madB.AA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "madB.AA") }) setMethod("madB.AB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "madB.AB") }) setMethod("madB.BB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "madB.BB") }) setReplaceMethod("madA.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "madA.AA", value) }) setReplaceMethod("madA.AB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "madA.AB", value) }) setReplaceMethod("madA.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "madA.BB", value) }) setReplaceMethod("madB.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "madB.AA", value) }) setReplaceMethod("madB.AB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "madB.AB", value) }) setReplaceMethod("madB.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "madB.BB", value) }) ##--------------------------------------------------------------------------- ## mad of log(intensities) by genotype cluster for each allele setMethod("tau2A.AA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "tau2A.AA") }) setMethod("tau2A.BB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "tau2A.BB") }) setMethod("tau2B.AA", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "tau2B.AA") }) setMethod("tau2B.BB", signature=signature(object="CNSet"), function(object) { assayDataElement(batchStatistics(object), "tau2B.BB") }) setReplaceMethod("tau2A.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "tau2A.AA", value) }) setReplaceMethod("tau2A.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "tau2A.BB", value) }) setReplaceMethod("tau2B.AA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "tau2B.AA", value) }) setReplaceMethod("tau2B.BB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "tau2B.BB", value) }) ## correlation of log2A and log2B within each genotype cluster setMethod("corrAA", signature=signature(object="CNSet"), function(object){ assayDataElement(batchStatistics(object), "corrAA") }) setMethod("corrAB", signature=signature(object="CNSet"), function(object){ assayDataElement(batchStatistics(object), "corrAB") }) setMethod("corrBB", signature=signature(object="CNSet"), function(object){ assayDataElement(batchStatistics(object), "corrBB") }) setReplaceMethod("corrAA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "corrAA", value) }) setReplaceMethod("corrAB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "corrAB", value) }) setReplaceMethod("corrBB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "corrBB", value) }) setReplaceMethod("phiPrimeA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "phiPrimeA", value) }) setReplaceMethod("phiPrimeB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "phiPrimeB", value) }) ##setMethod("mad.AA", signature=signature(object="CNSet"), function(object) mads(object, "AA")) ##setMethod("mad.AB", signature=signature(object="CNSet"), function(object) mads(object, "AB")) ##setMethod("mad.BB", signature=signature(object="CNSet"), function(object) mads(object, "BB")) ## ##setReplaceMethod("median.AA", signature=signature(object="CNSet", value="ff_or_matrix"), ## function(object, value){ ## linearParamElementReplace(object, "median.AA", value) ## }) ##setReplaceMethod("median.AB", signature=signature(object="CNSet", value="ff_or_matrix"), ## function(object, value){ ## linearParamElementReplace(object, "median.AB", value) ## }) ##setReplaceMethod("median.BB", signature=signature(object="CNSet", value="ff_or_matrix"), ## function(object, value){ ## linearParamElementReplace(object, "median.BB", value) ## }) ##setReplaceMethod("mad.AA", signature=signature(object="CNSet", value="ff_or_matrix"), ## function(object, value){ ## linearParamElementReplace(object, "mad.AA", value) ## }) ##setReplaceMethod("mad.AB", signature=signature(object="CNSet", value="ff_or_matrix"), ## function(object, value){ ## linearParamElementReplace(object, "mad.AB", value) ## }) ##setReplaceMethod("mad.BB", signature=signature(object="CNSet", value="ff_or_matrix"), ## function(object, value){ ## linearParamElementReplace(object, "mad.BB", value) ## }) setReplaceMethod("nuA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "nuA", value) }) setReplaceMethod("nuB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "nuB", value) }) setReplaceMethod("phiA", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "phiA", value) }) setReplaceMethod("phiB", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "phiB", value) }) setReplaceMethod("tau2A", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "tau2A", value) }) setReplaceMethod("tau2B", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "tau2B", value) }) setReplaceMethod("flags", signature=signature(object="CNSet", value="ff_or_matrix"), function(object, value){ linearParamElementReplace(object, "flags", value) }) setReplaceMethod("flags", signature=signature(object="CNSet", value="ff_matrix"), function(object, value){ linearParamElementReplace(object, "flags", value) }) setReplaceMethod("snpCall", "CNSet", function(object, value){ assayDataElementReplace(object, "call", value) }) setReplaceMethod("snpCallProbability", "CNSet", function(object, value){ assayDataElementReplace(object, "callProbability", value) })