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@UNPUBLISHED{Scharpf2009,
author = {Robert B Scharpf and Ingo Ruczinski and Benilton Carvalho and Betty
Doan and Aravinda Chakravarti and Rafael Irizarry},
title = {A multilevel model to address batch effects in copy number estimation
using SNP arrays},
month = {May},
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2ae7850e |
year = {2009},
url={http://www.bepress.com/cgi/viewcontent.cgi?article=1193&context=jhubiostat}
}
@ARTICLE{Carvalho2007a,
author = {Benilton Carvalho and Henrik Bengtsson and Terence P Speed and Rafael
A Irizarry},
title = {Exploration, normalization, and genotype calls of high-density oligonucleotide
SNP array data.},
journal = {Biostatistics},
year = {2007},
volume = {8},
pages = {485--499},
number = {2},
month = {Apr},
abstract = {In most microarray technologies, a number of critical steps are required
to convert raw intensity measurements into the data relied upon by
data analysts, biologists, and clinicians. These data manipulations,
referred to as preprocessing, can influence the quality of the ultimate
measurements. In the last few years, the high-throughput measurement
of gene expression is the most popular application of microarray
technology. For this application, various groups have demonstrated
that the use of modern statistical methodology can substantially
improve accuracy and precision of the gene expression measurements,
relative to ad hoc procedures introduced by designers and manufacturers
of the technology. Currently, other applications of microarrays are
becoming more and more popular. In this paper, we describe a preprocessing
methodology for a technology designed for the identification of DNA
sequence variants in specific genes or regions of the human genome
that are associated with phenotypes of interest such as disease.
In particular, we describe a methodology useful for preprocessing
Affymetrix single-nucleotide polymorphism chips and obtaining genotype
calls with the preprocessed data. We demonstrate how our procedure
improves existing approaches using data from 3 relatively large studies
including the one in which large numbers of independent calls are
available. The proposed methods are implemented in the package oligo
available from Bioconductor.},
doi = {10.1093/biostatistics/kxl042},
institution = {Department of Biostatistics, Johns Hopkins University, Baltimore,
MD 21205, USA.},
keywords = {Algorithms; Alleles; Data Interpretation, Statistical; Genotype; Humans;
Oligonucleotide Array Sequence Analysis; Oligonucleotides; Polymorphism,
Single Nucleotide},
owner = {rscharpf},
pii = {kxl042},
pmid = {17189563},
timestamp = {2008.08.07},
url = {http://dx.doi.org/10.1093/biostatistics/kxl042}
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