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Zhe Wang authored on 21/04/2019 21:30:01 • GitHub committed on 21/04/2019 21:30:01
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 # celda: CEllular Latent Dirichlet Allocation
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-"celda" stands for "**CE**llular **L**atent **D**irichlet **A**llocation", which is a suite of Bayesian hierarchical models and supporting functions to perform gene and cell clustering for count data generated by single cell RNA-seq platforms. This algorithm is an extension of the Latent Dirichlet Allocation (LDA) topic modeling framework that has been popular in text mining applications. Celda has advantages over other clustering frameworks:
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+"celda" stands for "**CE**llular **L**atent **D**irichlet **A**llocation". It is a suite of Bayesian hierarchical models and supporting functions to perform gene and cell clustering for count data generated by single cell RNA-seq platforms. This algorithm is an extension of the Latent Dirichlet Allocation (LDA) topic modeling framework that has been popular in text mining applications. Celda has advantages over other clustering frameworks:
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 1. Celda can simultaneously cluster genes into transcriptional states and cells into subpopulations
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 2. Celda uses count-based Dirichlet-multinomial distributions so no additional normalization is required for 3' DGE single cell RNA-seq