// ========================================================================== // SeqAn - The Library for Sequence Analysis // ========================================================================== // Copyright (c) 2006-2018, Knut Reinert, FU Berlin // All rights reserved. // // Redistribution and use in source and binary forms, with or without // modification, are permitted provided that the following conditions are met: // // * Redistributions of source code must retain the above copyright // notice, this list of conditions and the following disclaimer. // * Redistributions in binary form must reproduce the above copyright // notice, this list of conditions and the following disclaimer in the // documentation and/or other materials provided with the distribution. // * Neither the name of Knut Reinert or the FU Berlin nor the names of // its contributors may be used to endorse or promote products derived // from this software without specific prior written permission. // // THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS" // AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE // IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE // ARE DISCLAIMED. IN NO EVENT SHALL KNUT REINERT OR THE FU BERLIN BE LIABLE // FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL, EXEMPLARY, OR CONSEQUENTIAL // DAMAGES (INCLUDING, BUT NOT LIMITED TO, PROCUREMENT OF SUBSTITUTE GOODS OR // SERVICES; LOSS OF USE, DATA, OR PROFITS; OR BUSINESS INTERRUPTION) HOWEVER // CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER IN CONTRACT, STRICT // LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR OTHERWISE) ARISING IN ANY WAY // OUT OF THE USE OF THIS SOFTWARE, EVEN IF ADVISED OF THE POSSIBILITY OF SUCH // DAMAGE. // // ========================================================================== // Author: Rene Rahn <rene.rahn@fu-berlin.de> // ========================================================================== // Declares the DPCell, which is used to substitute the score of each cell. // Thus, we are able to add additional features to an alignment cell such as // a flag to indicate if it is forbidden or not. Or to store two additional // scores necessary for the affine gap function. // ========================================================================== #ifndef SEQAN_INCLUDE_SEQAN_ALIGN_DP_CELL_H_ #define SEQAN_INCLUDE_SEQAN_ALIGN_DP_CELL_H_ namespace seqan { // ============================================================================ // Forwards // ============================================================================ // ============================================================================ // Tags, Classes, Enums // ============================================================================ struct DynamicGapExtensionHorizontal_; typedef Tag<DynamicGapExtensionHorizontal_> DynamicGapExtensionHorizontal; struct DynamicGapExtensionVertical_; typedef Tag<DynamicGapExtensionVertical_> DynamicGapExtensionVertical; // ---------------------------------------------------------------------------- // Class DPCell_ // ---------------------------------------------------------------------------- // Used to store the score of a particular cell of the score matrix. // It can be specialized for linear and affine gap costs. // For affine gap costs it stores the values of all three matrices at a particular // position of the matrix. template <typename TScoreValue, typename TGapCosts> class DPCell_; // ============================================================================ // Metafunctions // ============================================================================ // ---------------------------------------------------------------------------- // Metafunction Spec // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapCostFunction> struct Spec<DPCell_<TScoreValue, TGapCostFunction> > { typedef TGapCostFunction Type; }; template <typename TScoreValue, typename TGapCostFunction> struct Spec<DPCell_<TScoreValue, TGapCostFunction> const> : Spec<DPCell_<TScoreValue, TGapCostFunction> > {}; // ---------------------------------------------------------------------------- // Metafunction Value // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapCostFunction> struct Value<DPCell_<TScoreValue, TGapCostFunction> > { typedef TScoreValue Type; }; template <typename TScoreValue, typename TGapCostFunction> struct Value<DPCell_<TScoreValue, TGapCostFunction> const> { typedef TScoreValue const Type; }; // ---------------------------------------------------------------------------- // Metafunction Reference // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapCostFunction> struct Reference<DPCell_<TScoreValue, TGapCostFunction> > { typedef TScoreValue & Type; }; template <typename TScoreValue, typename TGapCostFunction> struct Reference<DPCell_<TScoreValue, TGapCostFunction> const> { typedef TScoreValue const & Type; }; // ---------------------------------------------------------------------------- // Metafunction DPCellDefaultInfinity // ---------------------------------------------------------------------------- // Defines the default infinity value for a DPCell. template <typename T> struct DPCellDefaultInfinity { static const int VALUE; }; template <typename T> const int DPCellDefaultInfinity<T>::VALUE = std::numeric_limits<int>::min(); // We use the min value of the score type and shift it one bits to the left. This way we can use "infinity" without // checking for it during the computation. template <typename TScoreValue, typename TGapCostFunction> struct DPCellDefaultInfinity<DPCell_<TScoreValue, TGapCostFunction> > { static const TScoreValue VALUE; }; template <typename TScoreValue, typename TGapCostFunction> const TScoreValue DPCellDefaultInfinity<DPCell_<TScoreValue, TGapCostFunction> >::VALUE = createVector<TScoreValue>(std::numeric_limits<typename Value<TScoreValue>::Type>::min()) / createVector<TScoreValue>(2); template <typename TScoreValue, typename TGapCostFunction> struct DPCellDefaultInfinity<DPCell_<TScoreValue, TGapCostFunction> const> : public DPCellDefaultInfinity<DPCell_<TScoreValue, TGapCostFunction> >{}; // ---------------------------------------------------------------------------- // Metafunction StringSpecForValue_ // ---------------------------------------------------------------------------- // Defines the default infinity value for a DPCell. template <typename TValue, typename TSpec> struct StringSpecForValue_<DPCell_<TValue, TSpec> > { typedef typename If<Is<SimdVectorConcept<TValue> >, Alloc<OverAligned>, Alloc<> >::Type Type; }; template <typename TValue, typename TSpec> struct StringSpecForValue_<DPCell_<TValue, TSpec> const> : StringSpecForValue_<DPCell_<TValue, TSpec> > {}; // ============================================================================ // Functions // ============================================================================ // ---------------------------------------------------------------------------- // Function _scoreOfCell // ---------------------------------------------------------------------------- // Returns the score value for a given cell. template <typename TScoreValue, typename TGapCosts> inline typename Reference<DPCell_<TScoreValue, TGapCosts> >::Type _scoreOfCell(DPCell_<TScoreValue, TGapCosts> & dpCell) { return dpCell._score; } template <typename TScoreValue, typename TGapCosts> inline typename Reference<DPCell_<TScoreValue, TGapCosts> const>::Type _scoreOfCell(DPCell_<TScoreValue, TGapCosts> const & dpCell) { return dpCell._score; } // ---------------------------------------------------------------------------- // Function _setScoreOfCell // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapCosts> inline void _setScoreOfCell(DPCell_<TScoreValue, TGapCosts> & dpCell, TScoreValue const & newScore) { dpCell._score = newScore; } template <typename TScoreValue, typename TGapCosts, typename TMask> inline void _setScoreOfCell(DPCell_<TScoreValue, TGapCosts> & dpCell, TScoreValue const & newScore) { dpCell._score = newScore; } template <typename TScoreValue, typename TGapCosts, typename TMask> inline void _setScoreOfCell(DPCell_<TScoreValue, TGapCosts> & dpCell, TScoreValue const & newScore, TMask const & mask) { dpCell._score = blend(dpCell._score, newScore, mask); } // ---------------------------------------------------------------------------- // Function _verticalScoreOfCell() // ---------------------------------------------------------------------------- // Returns the score of the matrix for vertical-gaps of the given cell. template <typename TScoreValue, typename TGapSpec> inline typename Reference<DPCell_<TScoreValue, TGapSpec> >::Type _verticalScoreOfCell(DPCell_<TScoreValue, TGapSpec> & dpCell) { return dpCell._score; } template <typename TScoreValue, typename TGapSpec> inline typename Reference<DPCell_<TScoreValue, TGapSpec> const>::Type _verticalScoreOfCell(DPCell_<TScoreValue, TGapSpec> const & dpCell) { return dpCell._score; } // ---------------------------------------------------------------------------- // Function _setVerticalScoreOfCell() // ---------------------------------------------------------------------------- // Returns the score of the matrix for vertical-gaps of the given cell. template <typename TScoreValue, typename TGapSpec> inline void _setVerticalScoreOfCell(DPCell_<TScoreValue, TGapSpec> & /*dpCell*/, TScoreValue const & /*newVerticalScore*/) { // no-op } template <typename TScoreValue, typename TGapSpec, typename TMask> inline void _setVerticalScoreOfCell(DPCell_<TScoreValue, TGapSpec> & /*dpCell*/, TScoreValue const & /*newVerticalScore*/, TMask const & /*mask*/) { // no-op } // ---------------------------------------------------------------------------- // Function _horizontalScoreOfCell() // ---------------------------------------------------------------------------- // Returns the score of the matrix for horizontal-gaps of the given cell. template <typename TScoreValue, typename TGapSpec> inline typename Reference<DPCell_<TScoreValue, TGapSpec> >::Type _horizontalScoreOfCell(DPCell_<TScoreValue, TGapSpec> & dpCell) { return dpCell._score; } template <typename TScoreValue, typename TGapSpec> inline typename Reference<DPCell_<TScoreValue, TGapSpec> const>::Type _horizontalScoreOfCell(DPCell_<TScoreValue, TGapSpec> const & dpCell) { return dpCell._score; } // ---------------------------------------------------------------------------- // Function _setHorizontalScoreOfCell() // ---------------------------------------------------------------------------- // Returns the score of the matrix for vertical-gaps of the given cell. template <typename TScoreValue, typename TGapSpec> inline void _setHorizontalScoreOfCell(DPCell_<TScoreValue, TGapSpec> & /*dpCell*/, TScoreValue const & /*newHorizontalScore*/) { // no-op } template <typename TScoreValue, typename TGapSpec, typename TMask> inline void _setHorizontalScoreOfCell(DPCell_<TScoreValue, TGapSpec> & /*dpCell*/, TScoreValue const & /*newHorizontalScore*/, TMask const & /*mask*/) { // no-op } // ---------------------------------------------------------------------------- // Function setGapExtension() // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapSpec, typename TF1, typename TF2> inline void setGapExtension(DPCell_<TScoreValue, TGapSpec> & /*dpCell*/, TF1 , TF2) { // no-op } template <typename TScoreValue, typename TGapSpec, typename TF1, typename TF2, typename TMask> inline void setGapExtension(DPCell_<TScoreValue, TGapSpec> & /*dpCell*/, TF1 , TF2, TMask) { // no-op } template <typename TTarget, typename TScoreValue, typename TGapSpec> inline void write(TTarget & target, DPCell_<TScoreValue, TGapSpec> const & cell) { write(target, _scoreOfCell(cell)); } // ---------------------------------------------------------------------------- // Function isGapExtension() // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapSpec, typename TSpec> inline bool isGapExtension(DPCell_<TScoreValue, TGapSpec> const & /*cell*/, TSpec const & /*spec*/) { return false; } // ---------------------------------------------------------------------------- // Function operator==() // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapCosts> inline bool operator==(DPCell_<TScoreValue, TGapCosts> const & lhs, DPCell_<TScoreValue, TGapCosts> const & rhs) { return _scoreOfCell(lhs) == _scoreOfCell(rhs) && _horizontalScoreOfCell(lhs) == _horizontalScoreOfCell(rhs) && _verticalScoreOfCell(lhs) == _verticalScoreOfCell(rhs); } // ---------------------------------------------------------------------------- // Function operator!=() // ---------------------------------------------------------------------------- template <typename TScoreValue, typename TGapCosts> inline bool operator!=(DPCell_<TScoreValue, TGapCosts> const & lhs, DPCell_<TScoreValue, TGapCosts> const & rhs) { return !(lhs == rhs); } // ---------------------------------------------------------------------------- // Function operator<<() // ---------------------------------------------------------------------------- template <typename TStream, typename TScoreValue, typename TGapCosts> inline TStream& operator<<(TStream & stream, DPCell_<TScoreValue, TGapCosts> const & cell) { stream << "M: " << _scoreOfCell(cell); if (std::is_same<TGapCosts, AffineGaps>::value) { stream << " <H: " << _horizontalScoreOfCell(cell) << " V: " << _verticalScoreOfCell(cell) << ">"; } else if (std::is_same<TGapCosts, DynamicGaps>::value) { stream << " <H: " << isGapExtension(cell, DynamicGapExtensionHorizontal{}) << " V: " << isGapExtension(cell, DynamicGapExtensionVertical{}) << ">"; } return stream; } } // namespace seqan #endif // #ifndef SEQAN_INCLUDE_SEQAN_ALIGN_DP_CELL_H_