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README.md
# RITAN RITAN is an R package for Rapid Integration of Term Annotation and Network resources. RITAN brings together multiple resources to help answer two questions: 1. "What functions are achieved by this group of genes?" 2. "How do these genes work together to achieve that function?" Specifically, RITAN has been written to: 1. Identify terms/pathways/genesets represented by (enriched within) the input list of genes 2. Identify network interactions among the genes within the input list (protein-protein, metabolic, and regulatory) RITAN is to be applied to an unranked list of gene symbols and we perform false-discivery adjustment across all resources used. We encourage users to decide upon an analysis strategy prior to running their analysis, including consideration of which resources are most appropriate for their dataset/experiment, statistical significance thresholds, background geneset, etc. The ease with which RITAN facilitates multi-resource query may lead users to "try one more test," leading to an increased number of hypothesis tests made that may not be accounted for by multiple testing correction. To prevent this, we encourage users to "include one more resource" - to add an additional resource to a single query in RITAN so that false-dicovery correction is appropriately maintained. For additional examples of RITAN use, see our vignettes: * `vignette('enrichment',package='RITAN')` * `vignette('subnetworks',package='RITAN')`