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README.md
# PlinkMatrix: DelayedArray interface for plink genotypes Given a collection of .bed, .bim and .fam files produced for use with Plink, this package facilitates simple array-like operations for retrieving genotype data. ## Installation Use Bioconductor 3.23. ``` BiocManager::install("PlinkMatrix") ``` ## Example As an example, the GEUVADIS study genotypes distributed with tensorQTL were transformed to `geuv445.{bed,bim,fam}`. In a folder containing these files, we would proceed as follows to interrogate the genotypes. ``` > library(PlinkMatrix) > gdemo = example_PlinkMatrix() > colnames(gdemo) = gsub("0_", "", colnames(gdemo)) > gdemo <367759 x 445> DelayedMatrix object of type "double": HG00096 HG00097 HG00099 ... NA20826 NA20828 chr18_10644_C_G_b38 0 0 0 . 0 0 chr18_10847_C_A_b38 0 0 0 . 0 0 chr18_11275_G_A_b38 0 0 0 . 0 0 chr18_11358_G_A_b38 0 0 0 . 0 0 chr18_11445_G_A_b38 0 0 0 . 0 0 ... . . . . . . chr18_80259028_AG_A_b38 1 2 2 . 0 1 chr18_80259147_G_C_b38 0 0 0 . 0 0 chr18_80259181_A_G_b38 0 0 0 . 0 0 chr18_8025919C_G_b38 1 0 0 . 1 0 chr18_80259245_C_A_b38 0 0 0 . 0 0 ``` The associated data can be obtained in this package with `example_PlinkMatrix()`. See "Get started" tab above for more information.