Changes in version 2.6.0 (for BioC 3.5): - Many additions to the vignette and documentation. - LOD and POM (lines of descent, path of maximum, sensu Szendro et al.). - Diversity of sampled genotypes. - Genotyping error can be added in samplePop. - rfitness: shifting by subtraction and mu of normal distribution. - simOGraph: using proper transitive reduction. - Citation shows Bioinformatics paper. - Handling of trivial cases in genotFitness. - Clarified McFarland parameterization. - Better (and better explained) estimates of simulation error for McFL. - AND of detectedSizeP and lastMaxDr. - fixation of a genotype/gene as stopping mechanism. - sampledGenotypes in user code. - clonePhylog et al: deal with never any descendant. - samplePop can handle failed simulations graciously. - accessible genotypes now done in C++. - simOGraph can also output rT data frames. - clonePhylog et al: deal with never any descendant. - samplePop can handle failed simulations graciously. - summary.oncosimulpop can handle failed simulations graciously. Changes in version 2.5.13 (2017-04-07): - Updated NEWS for BioC 3.5. Changes in version 2.5.12 (2017-02-18): - rfitness: allow simple forcing of wt to 1, shifting by subtraction, and specifying mu of normal distribution. - simOGraph: proper trm comparison. - Citation now shows Bioinformatics reference. Changes in version 2.5.11 (2017-01-27): - Transitive reduction: must call transitive.closure first. Changes in version 2.5.10 (2017-01-27): - Transitive reduction: calling nem in simOGraph Changes in version 2.5.9 (2017-01-09): - Added code coverage comments to vignette. Changes in version 2.5.8 (2016-12-17): - Handle trivial cases in genotFitness. Changes in version 2.5.7 (2016-12-15): - Clarified McFarland parameterization. Changes in version 2.5.6 (2016-12-14): - Fixed a few typos in help files. Changes in version 2.5.5 (2016-12-14): - Vignette: miscell changes (typos, etc) Changes in version 2.5.4 (2016-12-12): - Vignette: miscell changes (order of examples, typos, etc) Changes in version 2.5.3 (2016-12-12): - Vignette uses pander in tables. - Typos fixed and other enhancements in vignette. Changes in version 2.5.2 (2016-12-10): - Lots and lots of addition to vignette including benchmarks. - Diversity of sampled genotypes. - Genotyping error can be added in samplePop. - LOD and POM (lines of descent, path of maximum, sensu Szendro et al.). - simOGraph can also out rT data frames. - Better (and better explained) estimates of simulation error for McFL. Changes in version 2.5.1 (2016-11-12): - AND of detectedSizeP and lastMaxDr. - fixation as stopping mechanism. - sampledGenotypes in user code. - clonePhylog et al: deal with never any descendant. - samplePop can handle failed simulations graciously. - summary.oncosimulpop can handle failed simulations graciously. - accessible genotypes now done in C++. - OcurringDrivers should not be a factor. - samplePop always returns gene names. - to_Magellan is much faster with rfitness objects. - Several improvements in vignette (English and additional explanations). Changes in version 2.4.0 (for BioC 3.4): - Mutator phenotype and gene-specific mutation rates. - End simulations stochastically as a function of size. - Specify fitness by giving genotype-> fitness mapping. - Random fitness landscape generation. - Plots of fitness landscapes. - Vignette: using Rmd. - Several improvements in help and vignette. - Improved test coverage. - samplePop: sample at arbitrary sizes. - evalAllGenotypes: order = FALSE by default. Changes in version 2.3.17 (2017-09-22): - random2 for rfitness. - Vignette: decrease size and running time. Changes in version 2.3.16 (2017-09-19): - Help was not accurate for some probSize args Changes in version 2.3.15 (2017-09-14): - Typo in name (progresion) Changes in version 2.3.14 (2017-08-26): - Documentation improvements. Changes in version 2.3.13 (2017-08-19): - bioRxiv citation. - Using Rmd for vignette. - Improvements in vignette. Changes in version 2.3.12 (2017-08-10): - Increase N in some tests. Changes in version 2.3.11 (2017-08-10): - evalAllGenotypes: order = FALSE by default. - Clarified difference plotFitnessEffects and plotFitnessLandscape. Changes in version 2.3.10 (2017-07-14): - The windows check failure with mc.cores. Changes in version 2.3.9 (2017-07-09): - Accessible genotypes in rfitness and plotFitnessLandscape Changes in version 2.3.8 (2017-07-08): - PDBasline default is now 1.2. Changes in version 2.3.7 (2016-07-05): - Unused C++ code reorganiz. - Added tests - Vignette and documentation improvements. - End simulations stochastically as a function of size. Changes in version 2.3.6 (2016-06-25): - Improved test coverage Changes in version 2.3.5 (2016-06-25): - to_Magellan. Changes in version 2.3.4 (2016-06-24): - Failing some tests in Win 32-bits Changes in version 2.3.3 (2016-06-23): - Vignette improvements and typo fixes. - rfitness: generate fitness landscapes. - Plot of fitness landscapes. - Specify fitness by giving genotype-> fitness mapping. - Tests showing same gene in epist./DAG/order. - Clarified internal C++ unique/sorted in genotypes. - Checks initMutant correct and bug initMutant mutable pos. - samplePop: sample at arbitrary sizes. - plot.oncosimulpop using auto for color. - Mutator phenotype and gene-specific mutation rates. - Bug fixed: to_update set at 2 when mutating to pre-existing. - Lots and lots of new tests. Changes in version 2.2.0 (for BioC 3.3): - Plots of genotypes. - Stacked area and stream plots (code from Marc Taylor). - Example of modules and no epistasis. - Removed requirement of Root in geneToModule. - More tests (and reorganized them) - Miscell. improvements and typos fixed in documentation and vignette. - Added mutationPropGrowth as argument. - Some minor bug fixes and additional checks for user errors. Changes in version 2.1.6 (2016-04-14): - Adapt to changes in today's release of testthat (1.0.0) Changes in version 2.1.5 (2016-04-09): - Added a test of driverCounts, that does not depend on OS/compiler. Changes in version 2.1.4 (2016-04-09): - Moved to manual tests that depend on OS/compiler (for reproduction of random number stream in C++). Changes in version 2.1.3 (2016-04-04): - Fixed sporadic bug in countDrivers Changes in version 2.1.2 (2016-03-27): - Arguments to BNB_Algo5 explicit. - Example of modules and no epistasis. - Removed requirement of Root in geneToModule. - More tests (and reorganized them) - Miscell. improvements in documentation and vignette. Changes in version 2.1.1 (2016-03-07): - Added mutationPropGrowth as argument. - Stacked area and stream plots (code from Marc Taylor). - Plots of genotypes. - Expanded vignette. Changes in version 1.99.9 (2015-10-08): - Fixed NEWS file. - Removed empty file. Changes in version 1.99.8 (2015-10-01): - Test "initMutant with oncoSimulSample, 2" occasionally failed. Changes in version 1.99.7 (2015-09-27): - initMutant available in oncoSimulPop and oncoSimulSample. Changes in version 1.99.6 (2015-09-26): - Improved test coverage and removed stringsAsfactors from tests. - Consistent handling of corner cases in Bozic. - Miscell minor documentation improvements. Changes in version 1.99.5 (2015-06-25): - Fixed bug in initMutant, added tests, and vignette section. Changes in version 1.99.4 (2015-06-22): - Plotting true phylogenies. - Tried randutils, from O'Neill. Won't work with gcc-4.6. - bool issue in Windows/gcc-4.6. - Most all to all.equal in tests. Changes in version 1.99.3 (2015-06-19): - More examples to vignette - Using Makevars - More functionality to plot.fitnessEffects - Will Windoze work now? Changes in version 1.99.2 (2015-06-19): - Fixed typos and other minor in vignett. Changes in version 1.99.1 (2015-06-18): - Try to compile in Windoze with the SSTR again. - Reduce size of RData objects with resaveRdaFiles. - Try to compile in Mac: mt RNG must include random in all files. Changes in version 1.99.01 (2015-06-17): - Many MAJOR changes: we are done moving to v.2 - New way of specifying restrictions (v.2) that allows arbitrary epistatic interactions and order effects, and very large (larger than 50000 genes) genomes. - When onlyCancer = TRUE, all iterations now in C++. - Many tests added. - Random DAG generation. - Some defaults for v.1 changed. Changes in version 1.99.00 (2015-04-23): - Accumulated changes of former 99.1.2 to 99.1.14: - changes in intermediate version 188.8.131.52 (2015-04-23): - Now are things OK (I messed up the repos) - changes in intermediate version 99.1.13 (2015-04-23) - Added a couple of drop = FALSE. Their absence lead to crashes in some strange, borderline cases. - Increased version to make unambiguous version used for anal. CBN. - changes in intermediate version 99.1.12 (2015-04-22) - Removed lots of unused conversion helpers and added more strict checks and tests of those checks. - changes in intermediate version 99.1.11 (2015-04-18) - Tests of conversion helpers now really working. - changes in intermediate version 99.1.10 (2015-04-16) - Added conversion helpers as separate file. - Added tests of conversion helpers. - Added generate-random-trees code (separate file). - More strict now on the poset format and conversions. - changes in intermediate version 99.1.9 (2015-04-09) - added null mutation for when we run out of mutable positions, and since not clear how to use BNB then. - changes in intermediate version 99.1.8 (2015-04-03) - added extraTime. - changes in intermediate version 99.1.7 (2015-04-03) - endTimeEvery removed. Now using minDDrPopSize if needed. - changes in intermediate version 99.1.6 (2015-03-20) - untilcancer and oncoSimulSample working together - changes in intermediate version 99.1.5 (2015-03-20) - Using the untilcancer branch - changes in intermediate version 99.1.4 (2014-12-24) - Added computation of min. of ratio birth/mutation and death/mutation. - changes in intermediate version 99.1.3 (2014-12-23) - Fixed segfault when hitting wall time and sampling only once. - changes in intermediate version 99.1.2 (2014-12-16) - Sampling only once Changes in version 0.99.2 (2014-07-14) - Consistently using indentation in .Rd files. Changes in version 0.99.1 (2014-07-14) - Minor changes for BioConductor submission: - extended description - minor changes to vignette - improved documentation of posets Changes in version 0.99.0 (2014-06-26) - First version submitted to BioConductor. Changes prior to the first BioC version. Left here for historical purposes simply. preBioC_1.0.4 2013-03-21 - Versions K, M, O, P working. - Versions O and P with u_1 and u_2 so as to provide comparable results to K and M. - Sometimes problems with ti==0. preBioC_1.0.5 2013-03-22 - Cleaned up the code and left only version P. - Added memory limits. preBioC_1.0.6 2013-03-22 - Added mutator genotype - Only species with fitness > 0 go through ti calculation. preBioC_1.0.7 2013-03-25 - Start run from a given mutation preBioC_1.0.8 2013-04-02 - Limits on outNS size to prevent segfaults. - Do not transpose outNS in R (do in C++). - Better code for sp_to_remove. preBioC_1.0.9 2013-04-02 - Some code in R moved to C++. - Minimize increases in RAM in R related to handling of temporaries. - Moved out of main R function the creation of rarely used objects. preBioC_1.0.10 2013-04-04 - Info on actual drivers returned from C++ preBioC_1.0.11 2013-04-04 - Added time limit to main C++ loop execution and changed exploration files accordingly. preBioC_1.0.12 2013-04-15 - Per sample driver and populations stats in C++. - Removed some rarely used output from C++. preBioC_1.0.13 2013-04-24 - Added continuous time Bozic fitness preBioC_1.0.14 2013-04-25 - Added Beerenwinkel et al., 2007 fitness. - Added a few checks for loss of precision. - Added thinning of output. preBioC_1.0.15 2013-04-26 - Unmet restrictions: allow variable penalty. - Safety initializations and a bug fix. preBioC_1.0.16 2013-05-01 - Unmet restrictions: better mechanism (which also fixes a bug). - Changed and cleared up the mess in the example trees. - This is the version used to launch the first set of massive simulations (bozic and exp) preBioC_1.0.17 2013-05-20 - Added McFarland et al. 2013 fitness. - Some code cleaning. - Fewer arguments in R function have default values (force user to be explicit). preBioC_1.0.18 2013-07-25 - Renamed the package - Tried to use Youn and Simon's method. Calling code added. - Tried to use Sakoparnig and Beerenwinkel's Bayesian CBN. Calling code added. - Fixed non-working code in metrics due to changes in functions in graph. - Added simple code for temporal order. - Added old code for clonal ordering (not finished). - Robustified other functions and start up (cbn, metrics, plotting, etc). - No dependencies on libgmp (multiprecission arith.) now; removed from Makevars. - Warning in R code if endTimeEvery is not negative in simulation models where it should probably be negative. preBioC_1.0.19 2014-xxx - Changes and addition to plotting functions. - Added comparison of adjacency matrices and other miscell functions from the processing code of the simulations.