Longitudinal Analysis of Cancer Evolution (LACE) ================ [](https://github.com/BIMIB-DISCo/LACE/actions?query=workflow%3Acheck-master) [](https://github.com/BIMIB-DISCo/LACE/actions?query=workflow%3Acheck-development) In this repository we provide an R implementation of *LACE*. *LACE* is an algorithmic framework that processes single-cell somatic mutation profiles from cancer samples collected at different time points and in distinct experimental settings, to produce longitudinal models of cancer evolution. The approach solves a Boolean Matrix Factorization problem with phylogenetic constraints, by maximizing a weighted likelihood function computed on multiple time points. Please feel free to contact us if you have problems running our tool at daniele.ramazzotti1@gmail.com or d.maspero@campus.unimib.it.