Package: HiLDA Type: Package Title: Conducting statistical inference on comparing the mutational exposures of mutational signatures by using hierarchical latent Dirichlet allocation Depends: R(>= 4.1), ggplot2 Imports: R2jags, abind, cowplot, grid, forcats, stringr, GenomicRanges, S4Vectors, XVector, Biostrings, GenomicFeatures, BSgenome.Hsapiens.UCSC.hg19, BiocGenerics, tidyr, grDevices, stats, TxDb.Hsapiens.UCSC.hg19.knownGene, utils, methods, Rcpp Suggests: knitr, rmarkdown, testthat, BiocStyle Version: 1.21.0 Date: 2021-10-13 Authors@R: c(person("Zhi", "Yang", email = "zyang895@gmail.com", role = c("aut", "cre")), person("Yuichi", "Shiraishi", email = "friend1ws@gmail.com", role = "ctb")) Description: A package built under the Bayesian framework of applying hierarchical latent Dirichlet allocation. It statistically tests whether the mutational exposures of mutational signatures (Shiraishi-model signatures) are different between two groups. The package also provides inference and visualization. License: GPL-3 URL: https://github.com/USCbiostats/HiLDA, https://doi.org/10.1101/577452 BugReports: https://github.com/USCbiostats/HiLDA/issues SystemRequirements: JAGS 4.0.0 biocViews: Software, SomaticMutation, Sequencing, StatisticalMethod, Bayesian RoxygenNote: 7.1.2 LinkingTo: Rcpp VignetteBuilder: knitr Encoding: UTF-8