git-svn-id: file:///home/git/hedgehog.fhcrc.org/bioconductor/trunk/madman/Rpacks/DEsubs@122029 bc3139a8-67e5-0310-9ffc-ced21a209358
1 | 1 |
new file mode 100644 |
... | ... |
@@ -0,0 +1,217 @@ |
1 |
+ |
|
2 |
+ |
|
3 |
+\name{subpathwayTypes} |
|
4 |
+\alias{subpathwayTypes} |
|
5 |
+\title{All subpathway types} |
|
6 |
+\usage{ |
|
7 |
+subpathwayTypes(grouping) |
|
8 |
+} |
|
9 |
+\arguments{ |
|
10 |
+\item{grouping}{By supplying one of the availiable groupings, specific |
|
11 |
+subsets of availiable subpathway types can be extracted.} |
|
12 |
+} |
|
13 |
+\value{ |
|
14 |
+A vector of all 124 basic subpathway types. See Details section for handly |
|
15 |
+groupings. |
|
16 |
+} |
|
17 |
+\description{ |
|
18 |
+All subpathway types. |
|
19 |
+} |
|
20 |
+\details{ |
|
21 |
+Apart from the 124 distinct subpathway types, several groupings are availiable: |
|
22 |
+\describe{ |
|
23 |
+\item{'all'}{ All subpathway options. } |
|
24 |
+\item{'all.bwd'}{ Forward propagation. } |
|
25 |
+\item{'all.fwd'}{Backward propagation. } |
|
26 |
+\item{'all.stream'}{All possible genes targeting or are targeted |
|
27 |
+via a path starting from a gene of interest.} |
|
28 |
+\item{'all.neighbourhood'}{All adjacent genes of a gene of interest with |
|
29 |
+incoming or outgoing links.} |
|
30 |
+\item{'all.cascade'}{A finite sequence of interactions connecting a sequence |
|
31 |
+of genes starting or ending from a gene of interest.} |
|
32 |
+\item{'all.community'}{Group of genes sharing common properties.} |
|
33 |
+\item{'all.component'}{Subgraphs on which any two vertices are (strongly) |
|
34 |
+connected to each other by paths.} |
|
35 |
+\item{ }{} |
|
36 |
+\item{'all.functional'}{Forward and backward streams starting from |
|
37 |
+genes/nodes with crucial functional role within the network. Individual |
|
38 |
+options include GO_bp, GO_cc, GO_mf, KEGG, Disease_OMIM, Disease_GAD, |
|
39 |
+Drug_DrugBank, miRNA, TF, DEG, which are defined below.} |
|
40 |
+\item{'all.GO_bp'}{Genes acting as a bridge among Gene Ontology (GO) |
|
41 |
+Biological Process terms. } |
|
42 |
+\item{'all.GO_cc'}{Genes acting as a bridge among Gene Ontology (GO) |
|
43 |
+Cellular Component terms. } |
|
44 |
+\item{'all.GO_mf'}{Genes acting as a bridge among Gene Ontology (GO) |
|
45 |
+Molecular Function terms. } |
|
46 |
+\item{'all.KEGG'}{Genes acting as a bridge among KEGG pathway maps. } |
|
47 |
+\item{'all.Disease_OMIM'}{Genes acting as a bridge among OMIM Disease |
|
48 |
+targets.} |
|
49 |
+\item{'all.Disease_GAD'}{Genes acting as a bridge among GAD Disease targets.} |
|
50 |
+\item{'all.Drug_DrugBank'}{Genes acting as a bridge among DrugBank Drug |
|
51 |
+targets.} |
|
52 |
+\item{'all.miRNA'}{Genes acting as a bridge among microRNA-gene targets. } |
|
53 |
+\item{'all.TF'}{Genes acting as a bridge among TF-gene targets. } |
|
54 |
+\item{'all.DEG'}{Genes with highly Differentially expressed by each |
|
55 |
+experimental data. } |
|
56 |
+\item{}{} |
|
57 |
+\item{'all.topological'}{Forward and backward streams starting from |
|
58 |
+genes/nodes with crucial topological role within the network. Individual |
|
59 |
+options include degree, betweenness, closeness, hub_score, eccentricity, |
|
60 |
+page_rank, start_nodes which are defined below.} |
|
61 |
+\item{'all.degree'}{Number of gene's adjacent interactions.} |
|
62 |
+\item{'all.betweenness'}{Number of shortest paths from all vertices to |
|
63 |
+others passing through a node.} |
|
64 |
+\item{'all.closeness'}{Inverse of farness, which is the sum of distances |
|
65 |
+to all other nodes.} |
|
66 |
+\item{'all.hub_score'}{Kleinberg's hub centrality score.} |
|
67 |
+\item{'all.eccentricity'}{Shortest path distance from the farthest other |
|
68 |
+node in the graph.} |
|
69 |
+\item{'all.page_rank'}{Google Page Rank.} |
|
70 |
+\item{'all.start_nodes'}{Gene nodes without incoming links.} |
|
71 |
+\item{}{} |
|
72 |
+} |
|
73 |
+ |
|
74 |
+An exhaustive list of all 124 subpathway types follows: |
|
75 |
+ |
|
76 |
+\tabular{ll}{ |
|
77 |
+ \tab \cr |
|
78 |
+ STREAM-TOPOLOGICAL \tab \cr |
|
79 |
+ 'bwd.stream.topological.degree' \tab |
|
80 |
+ 'fwd.stream.topological.degree' \cr |
|
81 |
+ 'bwd.stream.topological.betweenness' \tab |
|
82 |
+ 'fwd.stream.topological.betweenness' \cr |
|
83 |
+ 'bwd.stream.topological.closeness' \tab |
|
84 |
+ 'fwd.stream.topological.closeness' \cr |
|
85 |
+ 'bwd.stream.topological.hub_score' \tab |
|
86 |
+ 'fwd.stream.topological.hub_score' \cr |
|
87 |
+ 'bwd.stream.topological.eccentricity' \tab |
|
88 |
+ 'fwd.stream.topological.eccentricity' \cr |
|
89 |
+ 'bwd.stream.topological.page_rank' \tab |
|
90 |
+ 'fwd.stream.topological.page_rank' \cr |
|
91 |
+ 'bwd.stream.topological.start_nodes' \tab |
|
92 |
+ 'fwd.stream.topological.start_nodes' \cr |
|
93 |
+ \tab \cr |
|
94 |
+ STREAM-FUNCTIONAL \tab \cr |
|
95 |
+ 'bwd.stream.functional.GO_bp' \tab |
|
96 |
+ 'fwd.stream.functional.GO_bp' \cr |
|
97 |
+ 'bwd.stream.functional.GO_cc' \tab |
|
98 |
+ 'fwd.stream.functional.GO_cc' \cr |
|
99 |
+ 'bwd.stream.functional.GO_mf' \tab |
|
100 |
+ 'fwd.stream.functional.GO_mf' \cr |
|
101 |
+ 'bwd.stream.functional.KEGG' \tab |
|
102 |
+ 'fwd.stream.functional.KEGG' \cr |
|
103 |
+ 'bwd.stream.functional.Disease_OMIM' \tab |
|
104 |
+ 'fwd.stream.functional.Disease_OMIM' \cr |
|
105 |
+ 'bwd.stream.functional.Disease_GAD' \tab |
|
106 |
+ 'fwd.stream.functional.Disease_GAD' \cr |
|
107 |
+ 'bwd.stream.functional.Drug_DrugBank' \tab |
|
108 |
+ 'fwd.stream.functional.Drug_DrugBank' \cr |
|
109 |
+ 'bwd.stream.functional.miRNA' \tab |
|
110 |
+ 'fwd.stream.functional.miRNA' \cr |
|
111 |
+ 'bwd.stream.functional.TF' \tab |
|
112 |
+ 'fwd.stream.functional.TF' \cr |
|
113 |
+ 'bwd.stream.functional.DEG' \tab |
|
114 |
+ 'fwd.stream.functional.DEG' \cr |
|
115 |
+ \tab \cr |
|
116 |
+ NEIGHBOURHOOD-TOPOLOGICAL \tab \cr |
|
117 |
+ 'bwd.neighbourhood.topological.degree' \tab |
|
118 |
+ 'fwd.neighbourhood.topological.degree' \cr |
|
119 |
+ 'bwd.neighbourhood.topological.betweenness' \tab |
|
120 |
+ 'fwd.neighbourhood.topological.betweenness' \cr |
|
121 |
+ 'bwd.neighbourhood.topological.closeness' \tab |
|
122 |
+ 'fwd.neighbourhood.topological.closeness' \cr |
|
123 |
+ 'bwd.neighbourhood.topological.hub_score' \tab |
|
124 |
+ 'fwd.neighbourhood.topological.hub_score' \cr |
|
125 |
+ 'bwd.neighbourhood.topological.eccentricity' \tab |
|
126 |
+ 'fwd.neighbourhood.topological.eccentricity' \cr |
|
127 |
+ 'bwd.neighbourhood.topological.page_rank' \tab |
|
128 |
+ 'fwd.neighbourhood.topological.page_rank' \cr |
|
129 |
+ 'bwd.neighbourhood.topological.start_nodes' \tab |
|
130 |
+ 'fwd.neighbourhood.topological.start_nodes' \cr |
|
131 |
+ \tab \cr |
|
132 |
+ NEIGHBOURHOOD-FUNCTIONAL \tab \cr |
|
133 |
+ 'bwd.neighbourhood.functional.GO_bp' \tab |
|
134 |
+ 'fwd.neighbourhood.functional.GO_bp' \cr |
|
135 |
+ 'bwd.neighbourhood.functional.GO_cc' \tab |
|
136 |
+ 'fwd.neighbourhood.functional.GO_cc' \cr |
|
137 |
+ 'bwd.neighbourhood.functional.GO_mf' \tab |
|
138 |
+ 'fwd.neighbourhood.functional.GO_mf' \cr |
|
139 |
+ 'bwd.neighbourhood.functional.KEGG' \tab |
|
140 |
+ 'fwd.neighbourhood.functional.KEGG' \cr |
|
141 |
+ 'bwd.neighbourhood.functional.Disease_OMIM' \tab |
|
142 |
+ 'fwd.neighbourhood.functional.Disease_OMIM' \cr |
|
143 |
+ 'bwd.neighbourhood.functional.Disease_GAD' \tab |
|
144 |
+ 'fwd.neighbourhood.functional.Disease_GAD' \cr |
|
145 |
+ 'bwd.neighbourhood.functional.Drug_DrugBank' \tab |
|
146 |
+ 'fwd.neighbourhood.functional.Drug_DrugBank' \cr |
|
147 |
+ 'bwd.neighbourhood.functional.miRNA' \tab |
|
148 |
+ 'fwd.neighbourhood.functional.miRNA' \cr |
|
149 |
+ 'bwd.neighbourhood.functional.TF' \tab |
|
150 |
+ 'fwd.neighbourhood.functional.DEG' \cr |
|
151 |
+ \tab \cr |
|
152 |
+ CASCADE-TOPOLOGICAL \tab \cr |
|
153 |
+ 'bwd.cascade.topological.degree' \tab |
|
154 |
+ 'fwd.cascade.topological.degree' \cr |
|
155 |
+ 'bwd.cascade.topological.betweenness' \tab |
|
156 |
+ 'fwd.cascade.topological.betweenness' \cr |
|
157 |
+ 'bwd.cascade.topological.closeness' \tab |
|
158 |
+ 'fwd.cascade.topological.closeness' \cr |
|
159 |
+ 'bwd.cascade.topological.hub_score' \tab |
|
160 |
+ 'fwd.cascade.topological.hub_score' \cr |
|
161 |
+ 'bwd.cascade.topological.eccentricity' \tab |
|
162 |
+ 'fwd.cascade.topological.eccentricity' \cr |
|
163 |
+ 'bwd.cascade.topological.page_rank' \tab |
|
164 |
+ 'fwd.cascade.topological.page_rank' \cr |
|
165 |
+ 'bwd.cascade.topological.start_nodes' \tab |
|
166 |
+ 'fwd.cascade.topological.start_nodes' \cr |
|
167 |
+ \tab \cr |
|
168 |
+ \tab \cr |
|
169 |
+ CASCADE-FUNCTIONAL \tab \cr |
|
170 |
+ 'bwd.cascade.functional.GO_bp' \tab |
|
171 |
+ 'fwd.cascade.functional.GO_bp' \cr |
|
172 |
+ 'bwd.cascade.functional.GO_cc' \tab |
|
173 |
+ 'fwd.cascade.functional.GO_cc' \cr |
|
174 |
+ 'bwd.cascade.functional.GO_mf' \tab |
|
175 |
+ 'fwd.cascade.functional.GO_mf' \cr |
|
176 |
+ 'bwd.cascade.functional.KEGG' \tab |
|
177 |
+ 'fwd.cascade.functional.KEGG' \cr |
|
178 |
+ 'bwd.cascade.functional.Disease_OMIM' \tab |
|
179 |
+ 'fwd.cascade.functional.Disease_OMIM' \cr |
|
180 |
+ 'bwd.cascade.functional.Disease_GAD' \tab |
|
181 |
+ 'fwd.cascade.functional.Disease_GAD' \cr |
|
182 |
+ 'bwd.cascade.functional.Drug_DrugBank' \tab |
|
183 |
+ 'fwd.cascade.functional.Drug_DrugBank' \cr |
|
184 |
+ 'bwd.cascade.functional.miRNA' \tab 'fwd.cascade.functional.miRNA' \cr |
|
185 |
+ 'bwd.cascade.functional.TF' \tab 'fwd.cascade.functional.TF' \cr |
|
186 |
+ 'bwd.cascade.functional.DEG' \tab 'fwd.cascade.functional.DEG' \cr |
|
187 |
+ \tab \cr |
|
188 |
+ COMMUNITY \tab \cr |
|
189 |
+ 'community.walktrap' \tab 'community.edge_betweenness' \cr |
|
190 |
+ 'community.fast_greedy' \tab 'community.leading_eigen' \cr |
|
191 |
+ 'community.infomap' \tab 'community.louvain' \cr |
|
192 |
+ \tab \cr |
|
193 |
+ COMPONENT-CLIQUES \tab \cr |
|
194 |
+ 'component.max_cliques' \tab 'component.decompose' \cr |
|
195 |
+ 'component.3-cliques' \tab ... \cr |
|
196 |
+ ... \tab 'component.9-cliques' \cr |
|
197 |
+ \tab \cr |
|
198 |
+ COMPONENT-CORENESS \tab \cr |
|
199 |
+ 'component.3-coreness' \tab ... \cr |
|
200 |
+ ... \tab 'component.9-coreness' \cr |
|
201 |
+} |
|
202 |
+ |
|
203 |
+} |
|
204 |
+\examples{ |
|
205 |
+ |
|
206 |
+basic.types <- subpathwayTypes() |
|
207 |
+stream.types <- subpathwayTypes(grouping='all.stream') |
|
208 |
+ |
|
209 |
+} |
|
210 |
+ |
|
211 |
+ |
|
212 |
+ |
|
213 |
+ |
|
214 |
+ |
|
215 |
+ |
|
216 |
+ |
|
217 |
+ |