Package: BANDITS Type: Package Title: BANDITS: Bayesian ANalysis of DIfferenTial Splicing Version: 1.23.0 Author: Simone Tiberi [aut, cre]. Maintainer: Simone Tiberi <simone.tiberi@uzh.ch> Description: BANDITS is a Bayesian hierarchical model for detecting differential splicing of genes and transcripts, via differential transcript usage (DTU), between two or more conditions. The method uses a Bayesian hierarchical framework, which allows for sample specific proportions in a Dirichlet-Multinomial model, and samples the allocation of fragments to the transcripts. Parameters are inferred via Markov chain Monte Carlo (MCMC) techniques and a DTU test is performed via a multivariate Wald test on the posterior densities for the average relative abundance of transcripts. biocViews: DifferentialSplicing, AlternativeSplicing, Bayesian, Genetics, RNASeq, Sequencing, DifferentialExpression, GeneExpression, MultipleComparison, Software, Transcription, StatisticalMethod, Visualization License: GPL (>= 3) Depends: R (>= 4.3.0) Imports: Rcpp, doRNG, MASS, data.table, R.utils, doParallel, parallel, foreach, methods, stats, graphics, ggplot2, DRIMSeq, BiocParallel LinkingTo: Rcpp, RcppArmadillo Suggests: knitr, rmarkdown, testthat, tximport, BiocStyle, GenomicFeatures, Biostrings SystemRequirements: C++17 VignetteBuilder: knitr RoxygenNote: 7.2.3 ByteCompile: true URL: https://github.com/SimoneTiberi/BANDITS BugReports: https://github.com/SimoneTiberi/BANDITS/issues