# ANCOMBC ANCOMBC is a package containing differential abundance (DA) and correlation analyses for microbiome data. Specifically, the package includes Analysis of Compositions of Microbiomes with Bias Correction 2 (ANCOM-BC2, manuscript in preparation), Analysis of Compositions of Microbiomes with Bias Correction ([ANCOM-BC](https://doi.org/10.1038/s41467-020-17041-7)), and Analysis of Composition of Microbiomes ([ANCOM](https://www.tandfonline.com/doi/full/10.3402/mehd.v26.27663)) for DA analysis, and Sparse Estimation of Correlations among Microbiomes ([SECOM](https://doi.org/10.1038/s41467-022-32243-x)) for correlation analysis. Microbiome data are typically subject to two sources of biases: unequal sampling fractions (sample-specific biases) and differential sequencing efficiencies (taxon-specific biases). Methodologies included in the ANCOMBC package are designed to correct these biases and construct statistically consistent estimators. ## To install the latest release version of ANCOMBC ```r if (!requireNamespace("BiocManager", quietly=TRUE)) install.packages("BiocManager") BiocManager::install("ANCOMBC") ``` ## Usage ```r library(ANCOMBC) ?ancombc2 ?ancombc ?ancom ?secom_linear ?secom_dist ``` Author: Huang Lin Maintainer: Huang Lin: <huanglinfrederick@gmail.com>